JAMA Medical News

In this week's roundup, JAMA Medical News Director Jennifer Abbasi and Associate Managing Editor Kate Schweitzer discuss "What to Know About the WHO's New GLP-1 Guideline" and more.

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In this week's roundup, JAMA Medical News Director Jennifer Abbasi and staff writer Samantha Anderer discuss "Can Nicotine Pouches Help People Quit Smoking?" and more.

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In this week's roundup, JAMA Medical News Associate Managing Editor Kate Schweitzer and freelance writer and Harvard medical student Emily Harris discuss "A Growing Movement Aims to Prepare All Physicians to Care for Older Adults" and more.

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In this episode, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Medical News Director Jennifer Abbasi discuss the journal's inaugural Research of the Year roundup.

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Correction: an earlier version of this podcast misstated the phosphorylated tau analyte measured by the Roche blood biomarker test. It is p-tau181, not p-tau217.

In this week's roundup, JAMA Medical News Director Jennifer Abbasi and Lead Senior Staff Writer Rita Rubin discuss "Alzheimer Disease Blood Test Cleared for Primary Care, but Questions Remain About Its Use" and more.

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Updates on coffee and AFib, a polypill approach for HFrEF, the first oral PCSK9 inhibitor, vitamin D supplementation for secondary prevention, and more: Joanna Chikwe, MD, chair of the American Heart Association's Scientific Sessions conference and of the Department of Cardiac Surgery in the Smidt Heart Institute at Cedars-Sinai Medical Center, shares clinical research highlights from the recent meeting.

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In this week's roundup, JAMA Medical News Director Jennifer Abbasi and Associate Managing Editor Kate Schweitzer discuss "US Governors Are Forming a Public Health Alliance Amid Federal Funding Cuts and Shifting Guidance" and more.

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Updates on SGLT2 inhibitors, fish oil and hemodialysis, GLP-1 drugs, and more: Katherine R. Tuttle, MD, education committee co-chair of Kidney Week 2025 and a professor of medicine at the University of Washington, shares clinical research highlights from the recent meeting.

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In this weekly roundup, JAMA Medical News Director Jennifer Abbasi and Lead Senior Staff Writer Rita Rubin discuss "MASLD—The Chronic Liver Disease That Affects Tens of Millions of US Adults but Flies Under the Radar" and more.

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In this weekly roundup, JAMA Medical News Director Jennifer Abbasi and Staff Writer Samantha Anderer discuss "Peanut Allergies Appear to Be on the Decline Following Early Introduction Guidelines" and more.

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Dementia is still a highly stigmatized condition. Nancy Berlinger, PhD, a senior research scholar at The Hastings Center for Bioethics, discusses a new report about the cultural narratives of dementia and how they can affect the quality of life and the care of patients with the condition.

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State Laws Aim to Bring Internationally Trained Physicians to Underserved Areas, but Barriers Abound; Oral Microbiome Composition Linked to Pancreatic Cancer Risk

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A new European Society of Cardiology clinical consensus statement deals with cardiovascular disease prevention and management in COVID-19, including cardiac long COVID. The report's lead author, Vassilios Vassiliou, MBBS, PhD, MA, discusses the guidance and key questions that remain about COVID-19 and the heart.

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Epidemiologist Brian Lee, PhD, discusses his study on acetaminophen use during pregnancy and children's risk of autism and other neurodevelopmental disorders in this interview with JAMA Deputy Editor Linda Brubaker, MD.

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Ultraprocessed Foods and Cardiometabolic Health—New Report on a "Growing Public Health Challenge"; New Analysis of Women's Health Initiative Data Aims to "Clear the Air" Over Menopausal Hormone Therapy

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Updates on GLP-1 drugs in heart failure, β-blockers after myocardial infarction, the shingles vaccine, and more: Felix Mahfoud, MD, chair of the Department of Cardiology at University Hospital Basel, shares clinical research highlights from the recent European Society of Cardiology Congress.

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Pulmonologist Michael J. Welsh, MD, is the co-recipient of the 2025 Lasker-DeBakey Clinical Medical Research Award for his research on cystic fibrosis. In this interview, he discusses his early clinical encounters with the disease, the foundational work that led to the lifesaving drug Trikafta, and future directions for cystic fibrosis treatment.

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The Effects of Newly Changed Guidance on COVID-19 Shots During Pregnancy; Heart Disease Deaths Have Changed; Progress Toward a Norovirus Vaccine

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In this follow-up to a 2017 interview with JAMA Medical News, the University of Southern California's Maja Matarić, PhD, the computer scientist who pioneered the field of socially assistive robotics, discusses how artificial intelligence is advancing the field in areas ranging from autism to physical rehabilitation to anxiety and depression.

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New NIH-FDA Partnership Targets Nutrition Research Gaps; First Blood Test for Alzheimer Biomarkers Receives FDA Clearance; A Growing Movement to Care for Caregivers

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Kimmie Ng, MD, MPH, a JAMA associate editor and associate chief of the Division of Gastrointestinal Oncology at the Dana-Farber Cancer Institute, shares highlights from the American Society of Clinical Oncology's annual meeting, including new research on diet, exercise, and cancer survival and the best time of day for treatment.

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Delaying diagnosis of parkinsonism can mean delaying care. In a study recently published in JAMA Neurology, David Vaillancourt, PhD, and colleagues tested the ability of an AI model to differentiate between Parkinson disease and other neurodegenerative disorders when paired with MRI. He joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH to discuss.

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Federal Funds for Rural Health Care May Be Cut; Why the IV Fluid Shortage After Hurricane Helene Was Years in the Making; Surge in US Sports Betting Raises Public Health Concerns

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Susan Athey, PhD, of Standford University joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss her research on machine learning to target behavioral nudges for college students and their potential implications for health care.

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Ajay J. Kirtane, MD, SM, a professor of medicine at Columbia University Irving Medical Center, discusses late-breaking clinical research presented at the annual meeting of the American College of Cardiology in an interview with JAMA Medical News Director Jennifer Abbasi.

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Axe Falls on Federal Health Workforce; Experts Say CDC Cuts Will Cost Lives

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Diabetic retinopathy remains a leading cause of preventable blindness worldwide, and AI may facilitate screening, if such models continue to perform well when they are deployed in the real world. Coauthors Arthur Brant, MD, of Stanford University, and Sunny Virmani, MS, of Google join JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss a new study published in JAMA Network Open.

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A recent study published in JAMA Health Forum suggests that institutions may be able to deploy custom open-source large language models (LLMs) that run locally without sacrificing data privacy or flexibility. Coauthors Thomas A. Buckley, BS, and Arjun K. Manrai, PhD, from the Department of Biomedical Informatics at Harvard Medical School join JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss.

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Correction: This podcast has been updated to add additional context on the frequency of false positives.

Open neural tube defects affect approximately 1 in 1400 births. Daniel Herman, MD, PhD, of the University of Pennsylvania Perelman School of Medicine joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss a quality improvement study examining the need to continue to incorporate race in tests that screen for these defects.

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Artificial intelligence (AI) in health care is advancing, despite concerns about how its use may impact health disparities. Dimitri Christakis, MD, MPH, chief health officer at Special Olympics, joins JAMA Associate Editor Yulin Hswen, ScD, MPH, to discuss AI's potential role in improving health care delivery for people with intellectual and developmental disabilities.

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A recent study showed AI-assisted screening using a large language model tool reduced time to determine trial eligibility compared with manual methods. Author Alexander J. Blood, MD, MSc, cardiologist at Brigham and Women's Hospital, and Associate Director of the Accelerator for Clinical Transformation Research Group at Harvard Medical School joins JAMA Associate Editor Yulin Hswen, ScD, MPH, to discuss this topic and more.

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In a recent study published in JAMA Psychiatry, researchers reported that a machine learning model was able to stratify risk for subsequent diagnosis of schizophrenia or bipolar disorder among individuals already receiving psychiatric treatment. Coauthor Søren Dinesen Østergaard, PhD, of Aarhus University in Denmark joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss.

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A recent report from the Engineering Research Visioning Alliance emphasizes the urgent need for engineering-directed research to mitigate the growing threat of antimicrobial resistance. Anita Shukla, PhD, a professor of engineering at Brown University, discusses its findings with JAMA Medical News Associate Managing Editor Kate Schweitzer and presents several key opportunities.

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Changes to CDC's Website Threaten Patients, Public Health; Landmark Study of Black Women and Cancer Launches

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AI can play a role in addressing language barriers in health care. In a recent Editorial in JAMA Network Open, Pilar Ortega, MD, MGM, of the University of Illinois College of Medicine, and coauthors emphasized the urgent need for integrating language equity into digital health solutions. Dr Ortega joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss.

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Lung ultrasound aids in the diagnosis of patients with dyspnea but requires technical proficiency for image acquisition. Cristiana Baloescu, MD, MPH, of Yale School of Medicine, joins JAMA Associate Editor Yulin Hswen, ScD, MPH, to discuss a new study published in JAMA Cardiology evaluating the ability of AI to guide acquisition of diagnostic-quality lung ultrasound images by trained health care professionals.

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A recent study in JAMA Network Open evaluates the use of machine learning algorithms to assess the management of urinary tract infection (UTI). Author Sanjat Kanjilal, MD, MPH, professor in the Department of Population Medicine at Harvard Medical School and Harvard Pilgrim Healthcare Institute, joins JAMA Associate Editor Yulin Hswen, ScD, MPH, to discuss this topic and more.

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Digital health technologies, including patient portals, are widely used by older adults, as described in a recent study published in JAMA Network Open. Author Cornelius James, MD, of the University of Michigan joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss the study and how it fits with his own experience in the clinic.

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How do patients feel about the quality of AI-generated responses to their messages to clinicians? Author Eleni Linos, MD, DrPH, of Stanford joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss her recent study in JAMA Network Open that characterized satisfaction with these messages.

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The burden of responding to clinician inbox messages may be a contributor to burnout. Eden English, MD, of UCHealth joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss her recent study published in JAMA Network Open, which examined the use of large language models to reply to patient messages.

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With accelerating global adoption of AI, countries are developing ethical AI frameworks to prevent harm to the most vulnerable populations. Maria Villalobos-Quesada, PhD, from the National eHealth Living Lab (NeLL) in the Netherlands and the Observatory of Bioethics and Law of the University of Barcelona, discusses this and more with JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH. 

*Author image and affiliations updated February 4, 2025.

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American Indian and Alaska Native communities have higher rates of suicide than any other racial or ethnic group in the US. A recent study published in JAMA Network Open describes an AI-based suicide screening tool investigated in an American Indian community. Author Emily Haroz, PhD, of Johns Hopkins Bloomberg School of Public Health, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH.

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How can hospitals use early warning score tools to risk stratify patients without adding to alarm fatigue? Dana Edelson, MD, MS, of the University of Chicago joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss a recent study published in JAMA Network Open that she coauthored, comparing 6 early warning scores designed to recognize clinical deterioration in hospitalized patients.

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Chatbots may have a role in enhancing clinical care, but the best way to apply them remains a work in progress. Jonathen Chen, MD, PhD, and Ethan Goh, MD, MS, of Stanford, join JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss their randomized clinical trial published in JAMA Network Open investigating the use of chatbots in clinical practice.

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In a recent Viewpoint published in JAMA, Michael Pencina, PhD, of Duke University, argued for a federated registration system for AI tools deployed in health systems. He joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his article, the Coalition for Health AI (CHAI), and more.

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In resource-limited settings, an integrated AI tool allows novice users to improve gestational age estimates. Jeffrey Stringer, MD, University of North Carolina, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss "Diagnostic Accuracy of an Integrated AI Tool to Estimate Gestational Age From Blind Ultrasound Sweeps."

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Cardiologist Amit Khera, MD, chair of the American Heart Association's recent flagship meeting, discusses some of the most important clinical studies presented at the conference with JAMA Medical News Director Jennifer Abbasi. They touch on antiobesity drugs, new compounds to reduce lipoprotein(a), AI tools, and more.

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Effective communication is essential in medicine, yet language barriers can result in suboptimal care. AI holds promise for bridging these gaps, enhancing outcomes, and reducing disparities. Casey Lion, MD, MPH, from the University of Washington School of Medicine, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss AI as an interpreter in the clinic.

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A recent Special Communication published in JAMA points out that the FDA has already approved nearly 1000 devices using AI. Author Robert M. Califf, MD, commissioner of the US Food and Drug Administration, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss AI regulation.

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A recent JAMA Cardiology essay argues that medicine is not just a technical endeavor, it's also a moral endeavor, and a robot does not have moral agency. Coauthor Sarah C. Hull, MD, MBE, of Yale School of Medicine, joins JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, to discuss the use of AI in managing decision-making in cardiac care.

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Widespread adoption of AI raises questions about accountability, transparency, and reproducibility. Marcia McNutt, PhD, president of the National Academy of Sciences, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss advancing scientific knowledge in the age of AI.

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Researchers Are Exploring the Role of Shingles—and a Protective Role of Shingles Vaccine—in Dementia; Could the Body Roundness Index One Day Replace BMI?

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Getting genuinely useful new technologies, from wearables to clinical decision support, into the clinic has proven to be surprisingly challenging. Tanzeem K. Choudhury, PhD, of Cornell Tech joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss how to take research into the real world in a way that is scalable and affordable.

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What hard lessons did the US Department of Veterans Affairs (VA) learn in 3 decades of EHR development, and what can it teach us about building better AI in medicine? Stephen Fihn, MD, MPH, of the University of Washington, and formerly a leader in the VA's EHR efforts, joins JAMA+ AI Editor in Chief Roy H. Perlis, MD, MSc, to discuss his experience at the VA building decision support tools and other technology.

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European Society of Cardiology Vice President Carlos Aguiar, MD, discusses clinical research highlights from the largest scientific meeting in cardiovascular medicine, held recently in London. Updates include semaglutide findings, hypertension triple pills, and more.

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Quarraisha Abdool Karim, PhD, and Salim S. Abdool Karim, MBChB, PhD, are the recipients of the 2024 Lasker-Bloomberg Public Service Award for their decades of work on AIDS in Africa. The infectious diseases epidemiologists recently reflected on their life's work in a conversation with JAMA Deputy Editor and infectious diseases physician Preeti Malani, MD, MSJ.

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Extreme heat and its health outcomes are becoming more common. Jeremy Hess, MD, MPH, an emergency medicine physician and professor at the University of Washington, and Andrew Phelps, former director of the Oregon Department of Emergency Management, join Jennifer Abbasi, director of JAMA Medical News, to discuss lessons learned from the unprecedented heat wave in June 2021.

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Sebastian Palmqvist, MD, PhD, and Wiesje van der Flier, PhD, cochairs of the 2024 Alzheimer's Association International Conference, speak with JAMA Medical News Lead Senior Staff Writer Rita Rubin, MA, about highlights from the annual meeting, including a blood test for Alzheimer disease, repurposing of a GLP-1 receptor agonist, and the possible brain risk from inhaling wildfire smoke.

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Social media is the focus of the US surgeon general's conversation with JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS. She interviews Vivek H. Murthy, MD, MBA, to discuss the dangers of social media on youth mental health, highlighting its contribution to the epidemic of loneliness. This is part 2 of a 2-part Q&A.

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Endocrinologist Robert Gabbay, MD, PhD, the ADA's chief scientific and medical officer, speaks with JAMA Medical News about clinical research highlights from the annual meeting, including some of the latest data on blockbuster weight loss medications, "game-changing" diabetes technologies, and a new use for a familiar drug.

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Which Variant Will Updated COVID-19 Vaccines Target This Fall? COVID-19 May Protect Against the Common Cold

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This is a 2-part Q&A series with the US Surgeon General. In part 1, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, interviews Vivek H. Murthy, MD, MBA, to discuss the issue of gun violence as a pressing public health crisis and the critical role of public health leadership in combating this issue.

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Nora Disis, MD, editor in chief of JAMA Oncology and a JAMA deputy editor, and guests share JAMA Network highlights from the American Society of Clinical Oncology's annual meeting, including new research on colorectal cancer screening, an antibody therapy for non–small cell lung cancer, access to oncology clinical trials, and a new model of palliative care for patients with cancer.

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Can data from wearable devices and electronic health records enhance quality improvement in health care? In this Q&A, Sachin Kheterpal, MD, MBA, the University of Michigan Medical School Associate Dean for Research Information Technology, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the potential of data from mobile devices to revolutionize patient care.

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Daniel Gibbs, MD, received an Alzheimer disease diagnosis 8 years ago, and in hindsight, believes the earliest symptoms appeared years before that. In this podcast, the retired neurologist speaks with JAMA Medical News lead senior staff writer Rita Rubin, MA, about how even with the neurodegenerative condition, it's still possible to enjoy a life well-lived.

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Can AI augment radiological processes, imaging analysis, and diagnosis? In this Q&A, Saurabh Jha, MBBS, MRCS, MS, an associate professor of radiology at the University of Pennsylvania, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss how AI could play a crucial role in improving access to medical imaging in remote, high-altitude, and low-income areas.

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Can AI/machine learning-driven digital phenotyping facilitate global personalized medicine? In this Q&A, Vikram Patel, MBBS, PhD, the Paul Farmer Professor and chair of the Department of Global Health and Social Medicine at Harvard Medical School, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss how AI can enhance assessment and treatment solutions across lower-income nations.

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Douglas Drachman, MD, shares late-breaking research from the annual conference of the American College of Cardiology and World Congress of Cardiology in an interview with JAMA Medical News Director Jennifer Abbasi. Dr Drachman—who chaired this year's conference—is an interventional cardiologist at Massachusetts General Hospital, where he is also director of education in the cardiology division.

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Momentum Grows for Disaggregated Asian American Health Data; What Clinicians Need to Know About TikTok

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Could generative AI assist in extending access to vulnerable populations and begin to bridge the gap in disparities? In this Q&A, Davey Smith, MD, MAS, an infectious disease specialist and virologist at the University of California, San Diego, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to explore the implications of large language models for improving patient outcomes.

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AI can understand brain signals linked to the sensory and motor processes involved in speech. In this Q&A, Edward Chang, MD, the chair and professor of neurosurgery at UCSF joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss how AI has the potential to facilitate communication and how close AI development is to being able to translate human emotion.

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Can AI enhance the speed and efficiency of interpreting ultrasounds and echocardiograms, thereby minimizing diagnostic errors? In this Q&A, Rima Arnaout, MD, a cardiologist and associate professor of medicine at the University of California-San Francisco, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the transformative impact of AI on cardiac imaging.

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Automation bias and shortcuts in clinical AI models have posed significant challenges. In this Q&A, Jenna Wiens, PhD, an associate professor of Computer Science and Engineering at the University of Michigan in Ann Arbor, joins JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss how we can start leveraging human collaboration with AI to provide more effective health care.

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AI in clinical practice needs ethical frameworks to avert future biases. In this Q&A, Marzyeh Ghassemi, PhD, the Herman L. F. von Helmholtz Career Development Professor at MIT in Electrical Engineering and Computer Science (EECS), joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss ethical machine learning and responsible clinical implementation.

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How can we leverage AI to transform health care into a more efficient model for delivering care? In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, interviews Atul Butte, MD, PhD, the director of the Bakar Computational Health Sciences Institute at UCSF, to discuss scalable privilege and the need for the broad distribution of AI-driven expertise.

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Amid the surging buzz around artificial intelligence (AI), can we trust the Al hype, and more importantly, are we ready for its implications? In this Q&A, Arvind Narayanan, PhD, a professor of computer science at Princeton, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the exploration of Al's fairness, transparency, and accountability.

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Artificial intelligence holds the promise of revolutionizing disease diagnosis and prediction, but it also presents a pivotal challenge: ensuring equity. In this Q&A, Alondra Nelson, PhD, the Harold F. Linder Professor at the Institute for Advanced Study, joins JAMA's Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, to discuss the equitable regulation of AI to benefit all populations.

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In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, interviews John Ayers, PhD, MA, vice chief of innovation in the Division of Infectious Diseases & Global Public Health, deputy director of informatics in the Altman Clinical and Translational Research Institute, and affiliate scientist in the Qualcomm Institute, all at UC San Diego, to discuss how genAI programs like ChatGPT can increase communication pathways and improve patient outcomes.

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JAMA Associate Editor Gregory Marcus, MD, a cardiologist and professor of medicine at the University of California San Francisco, speaks with American Heart Association Scientific Sessions 2023 conference chair Amit Khera, MD, MSc, a professor in the department of internal medicine at UT Southwestern Medical Center and the director of preventive cardiology.

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In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, interviews Nigam Shah, MBBS, PhD, professor of medicine at Stanford University and chief data scientist at Stanford Health Care, to discuss how large language models are reshaping medicine and the potential pitfalls of automation.

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New vaccines, artificial intelligence, antimicrobial resistance, and more—JAMA Deputy Editor Preeti Malani, MD, MSJ, speaks with IDWeek 2023 cochair Col Heather Yun, USAF, MC. The infectious disease physicians discuss clinical highlights from the conference.

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JAMA Associate Editor John M. Inadomi, MD, discusses clinical highlights from United European Gastroenterology (UEG) Week with UEG president Helena Cortez-Pinto, MD, PhD.

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AI has potential to meaningfully improve patient care. How will AI advances help clinicians focus on the best use of their time and talents? In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, interviews Suchi Saria, PhD, MSc, an associate professor in computer science at Johns Hopkins, to discuss how AI could streamline care.

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