The Human 5.0 Project

In this episode of "Peptides for Dummies 2026," we explore the world of powerful peptides that support healing, boost immunity, and enhance overall vitality. Join Ultimate Biohacker 10X as we break down:

KPV: A tripeptide that reduces gut inflammation and supports immune health.

KLOW Peptide: A blend that promotes healing and reduces inflammation.

BPC-157: Known for its remarkable healing properties for muscles, tendons, and the gut.

TB-500 and TB-4: Peptides that enhance tissue repair and regeneration.

Thymosin Alpha-1: A peptide that boosts the immune system.

MOTS-c: A mitochondrial p...

In this episode of "Peptides for Dummies 2026," we explore the world of powerful peptides that support healing, boost immunity, and enhance overall vitality. Join Ultimate Biohacker 10X as we break down:

KPV: A tripeptide that reduces gut inflammation and supports immune health.

KLOW Peptide: A blend that promotes healing and reduces inflammation.

BPC-157: Known for its remarkable healing properties for muscles, tendons, and the gut.

TB-500 and TB-4: Peptides that enhance tissue repair and regeneration.

Thymosin Alpha-1: A peptide that boosts the immune system.

MOTS-c: A mitochondrial p...

PEG-MGF 2026: The pegylated version of Mechanical Growth Factor (MGF/IGF-1Ec) hyped for muscle repair, hypertrophy, recovery, and anti-aging—but banned worldwide in sports. In this morning episode of The Human 5.0 Project, Ultimate Biohacker 10X covers:

If you're chasing faster gains, injury recovery, or longevity mu...

Your brain wasn’t designed for screens, straight lines, and constant alerts.

It was designed for patterns.

In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the neuroscience behind nature’s fractals — the repeating patterns found in trees, waves, clouds, and coastlines — and why they rapidly restore focus, reduce stress, and improve mental performance.

We explore:

Attention Restoration Theory (ART) — why modern life drains your brain

What “soft fascination” really means (and why it matters)

How mid-range fractals reduce cortisol, boost alpha brain waves, and improve he...

Welcome to The Human 5.0 Project! In this episode, Ultimate Biohacker 10X dives into SNAP-8, the octapeptide that’s challenging Botox in 2026. We explore:

Origin & History: The journey from Argireline to SNAP-8.

Mechanism: How SNAP-8 works to relax expression lines topically.

Clinical Data: Efficacy and limitations in real-world studies.

Cosmetic & Biohacking Use: Topical applications, DIY stacks, and more.

Comparisons: SNAP-8 vs Argireline vs Botox.

If you're curious about non-injectable anti-aging solutions, this is your 2026 reality check!

Disclaimer: Educational content only; not medical advice. Always consult a de...

Welcome back to The Human 5.0 Project! On this episode, Ultimate Biohacker 10X breaks down the 2026 landscape for reversing androgenetic alopecia and waking dormant follicles. We cover:

Liposomal Peptides in 2026: Are oral liposomal formulations (BPC-157, GHK-Cu, epitalon & more) a game-changing way to get peptide benefits without injections... or just a clever marketing tactic to dodge FDA restrictions on compounded injectables?

In this no-hype episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks it down:

Are lyophilized exosomes the future of regenerative medicine—or a dangerous shortcut around science and regulation?

In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down one of the most controversial claims in regenerative clinics today: that exosomes can be freeze-dried, stored at room temperature, reconstituted with saline, and safely injected.

We examine:
• What exosomes actually are (and why they’re fragile)
• What the human clinical evidence does—and doesn’t—support
• FDA warnings and real adverse event reports
• Why convenience claims often hide regulatory shortcuts
• The exact questions every pati...

Exosome Therapy 2026: The Next Frontier in Cellular Regeneration & Anti-Aging (But Is It Hype?)

Forget the "miracle cure" claims—let's break down the real science behind exosomes in 2026.

Hey biohackers, longevity rebels, and loyalists—this is Ultimate Biohacker 10X on The Human 5.0 Project. We're diving deep into exosome therapy: the cell-free alternative to stem cells that's exploding in regen medicine. But with massive hype, FDA warnings, and early clinical data, what's actually legit?

⚠️ Important Disclaimer: This is educational content only—not medical advice. No exosome products are FDA-approved for disease treatment as of 2026. Many clinic off...

“Zombie cells” aren’t a meme—senescent cells accumulate with age, pump out inflammatory signals (SASP), and can sabotage joints, lungs, vessels, brain health, and recovery. In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real science of senolytics: where the concept came from, what senescent cells actually do, how senolytics work (and why dosing in trials is pulsed), and what the human evidence looks like so far.

We cover:

What senescent cells are + why they accumulate (Hayflick limit → modern aging biology) ScienceDirect

SASP: the inflammatory “broadcast” that damages nearby tissue...

“Zombie cells” aren’t a meme—senescent cells accumulate with age, pump out inflammatory signals (SASP), and can sabotage joints, lungs, vessels, brain health, and recovery. In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real science of senolytics: where the concept came from, what senescent cells actually do, how senolytics work (and why dosing in trials is pulsed), and what the human evidence looks like so far.

We cover:

What senescent cells are + why they accumulate (Hayflick limit → modern aging biology) ScienceDirect

SASP: the inflammatory “broadcast” that damages nearby tissue...

Everyone’s “fixing their gut” in 2026… and half the people are accidentally making it worse.

If you’ve ever said:
“I took a probiotic and got MORE bloated,”
this episode is for you.

Today on The Human 5.0 Project, we end the confusion for good:
✅ What probiotics actually are (and why CFU hype is misleading)
✅ What prebiotics are (and why they’re the missing piece)
✅ How probiotics + prebiotics work together (synbiotics)
✅ The real 2026 dose basics + why “more strains” can backfire
✅ Testing that actually helps vs. expensive graphs with no action plan
✅ Red flags (S...

Tesamorelin (Egrifta / Egrifta SV) is one of the most discussed “longevity-adjacent” tools in 2026—because it targets visceral fat (the fat around organs that drives metabolic aging), while stimulating natural growth hormone pulses through the GHRH pathway.

In this episode, we go origin-to-clinic:
✅ What tesamorelin is (and why it’s different than straight HGH)
✅ The HIV lipodystrophy approval story + what the data actually showed
✅ Why longevity / functional medicine clinics are using it off-label in 2026
✅ Practical dosing ranges discussed in clinics, cycling strategies, and timing
✅ Popular combinations (fasting, peptides, glucose-support strategies)
✅ Who tends to benefit most—and...

In this episode, we dive deep into the science of healthy fats, focusing on olive oil, avocado oil, and coconut oil. Discover why these oils stand out, how they impact blood sugar and overall health, and which one might be best for you. Learn practical tips for incorporating them into your diet and what to look for when choosing quality oils.

Free Download: 3-Fat Cheat Sheet with meal-pair chart and dosage guide.

For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.

And if...

Welcome to The Human 5.0 Project! In this episode, we dive into KPV, a groundbreaking tripeptide that’s making waves in the world of inflammation control. Discover its origins, the science behind its anti-inflammatory properties, and how it’s being explored in clinical and real-world settings. We’ll also explore dosing protocols and the latest findings from global research.

Disclaimer: This content is for educational purposes only and not medical advice. Always consult a healthcare professional before considering any peptide or experimental therapy.

Free Download: KPV Quick-Reference Card (Link in Description)

For mo...

From identity-based habits to dopamine rewiring, we’re diving into the real science of lasting weight loss in 2026.

What you’ll learn:

The shocking stats on why most diets fail within 19 days.

How to shift from “I want to lose 20 lbs” to “I’m the kind of person who…” and why that changes everything.

How to engineer your environment and rewire your brain’s reward system to make healthy choices automatic.

Why the 66-day habit rule beats perfection every time.

If you’re ready to ditch diet culture and build la...

From strength training myths to fezolinetant (Veozah) and GH pathways — this is the full 2026 science-backed blueprint.

Today is the Menopause Biohacking Blueprint (2026) — the real, evidence-first playbook for hot flashes, sleep disruption, belly fat, mood swings, and brain fog. No fluff. No vendor ads. Just science — and a roadmap that actually works in the real world.

In this episode, we break down:

Why menopause isn’t “aging” — it’s a metabolic event (estrogen decline → insulin sensitivity shifts → visceral fat ↑ → muscle loss risk ↑)

The 3 non-negotiables for women 40+: muscle, insulin sensitivity, sleep

Time-restricted eating + t...

Today we’re going deep on mitochondria (your cellular energy engines) and senolytics (tools being studied to clear “senescent” zombie cells that sabotage recovery, inflammation, and performance). No fluff. No vendor ads. Just PubMed-backed science and what the global research is actually pointing to in 2026.

In this episode, we break down:

What mitochondria are, what they do, and why they decline with age

The lifestyle levers that reliably boost mitochondrial function (training, sleep, fasting, heat/cold)

Mitochondria-targeted nutrition + supplements (NR/NMN, CoQ10, PQQ, urolithin A, spermidine, ALA/ALCAR, olive oil polyphenols)

oday we’re diving into Delta Sleep-Inducing Peptide (DSIP) — the nonapeptide that’s been studied for decades in relation to sleep, stress physiology, pain, and even withdrawal states. And we’re doing this the right way: PubMed-backed facts only — no peptide-vendor hype.

In this episode:

Where DSIP came from (the 1970s origin story + sequence)

What human studies actually looked at (insomnia trials, mixed results)

Evidence for pain and withdrawal applications (older clinical literature)

Where DSIP shows up in the world’s medical literature (including DSIP-containing preparations like “Deltaran”)

The reality ch...

Longevity isn't about chasing magic pills — it’s a race won through paradigm shifts, embracing discomfort, and sustainable habits. In this episode, Ultimate Biohacker 10X breaks down why food is medicine, why women should lift heavy (busting the "bulky" myth), how to reframe exercise and nutrition, and practical 2026 strategies for healthspan.

Key insights:

Food as drug: Quality fiber, protein, and polyphenols for microbiome and inflammation control.

Strength training myths: Women gain metabolism, bone density, and hormone balance — not bulk.

Embracing discomfort: Small stresses (cold, fasting, heavy lifts) build resilience.

Sustai...

Welcome back to The Human 5.0 Project with Ultimate Biohacker 10X! In this episode of the  Podcast, we dive into "The Longevity Dilemma: Navigating Biohacking Hype vs. Evidence-Based Science."

In a world buzzing with cutting-edge tech, peptides, and supplements, it’s easy to get lost in the hype. From miraculous claims of instant youth to peptides that promise to melt fat effortlessly, we’ll explore how to separate the real science from the marketing noise.

In this episode, you'll learn:

The psychology behind why we’re drawn to quick fixes and shortcuts.

Practic...

Tonight we’re breaking down Dihexa (PNB-0408) — the angiotensin IV analog that gets called “synapse-building on steroids.” People throw around claims like “stronger than BDNF” and “neurogenesis peptide,” but what’s real… and what’s internet mythology?

In this episode, we go raw + evidence-first:

What Dihexa actually is (and what it’s not)

The real mechanism: HGF / c-Met signaling and why that matters for synapses

What animal studies suggest (and where it doesn’t translate cleanly)

Oral activity + BBB penetration claims from early research

Why formulation/solubility is a headache (and why tha...

In Part 2 on 5-Amino-1MQ (5A1MQ), we get practical and responsible: how to think like a researcher, how to interpret viral before/afters without getting played, what biomarkers actually matter, and what “oral dosing” patterns are commonly claimed online as of 2026—with a clear reminder that this is not a standardized, published human dosing regimen.

This episode is NOT medical advice. 5-Amino-1MQ is a research compound and is not FDA-approved to treat or prevent any condition. If you suspect metabolic disease, celiac disease, or you’re on medications, talk to a qualified clinician.

In this...

Is 5-Amino-1MQ (5A1MQ) the “fat-loss NAD+ compound” people claim—or is it just early-stage science getting overhyped? In this episode, JP (UltimateBiohacker10x / The Human 5.0 Project) breaks down what 5A1MQ actually is, how NNMT inhibition works, what the best animal data shows for obesity and fatty liver, what we’re seeing in aged muscle performance studies, and the most important part: what we still do NOT know in humans as of January 2026.

Key sources (for show notes):

NNMT inhibitor 5A1MQ cell/NAD+ findings (Neelakantan et al., 2017). PMC

DIO mouse obesity...

Welcome to The Human 5.0 Project with UltimateBioHacker10X.

Gluten has become the internet’s favorite scapegoat—but here’s the weird part: people who feel terrible after bread in the U.S. often report feeling totally fine eating bread in France, Italy, or Spain. Same person… different bread. So what’s really going on?

In this episode, we unpack:

Why US flour processing can be radically different (bleaching, enrichment, shelf-life priorities)

How long fermentation / sourdough-style methods may change digestibility

The role of additives & dough conditioners (and why ingredient lists matter) Duration: 00:06:32

Welcome back to The Human 5.0 Project with UltimateBioHacker10X

In Part 2 on SLU-PP-332, we skip the hype and talk side effects and the biggest online rumor: cardiomyopathy / heart risk. We break down what people commonly report anecdotally (like flushing, water retention, and fatigue when dosing too aggressively) and then zoom out to what preclinical mouse data can—and can’t—tell us about cardiac safety (histology, fibrosis signals, and functional echo-style outcomes).

Important: SLU-PP-332 is a preclinical research compound and is not approved for human use. This content is for education only and is not medica...

Most people chase growth hormone peptides without understanding how the pituitary actually works — and that’s how you end up with hormone shutdown, stalled gains, or long-term damage.

In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down growth hormone–releasing peptides in plain English using a simple “phone call” analogy so you finally understand what these compounds actually do inside your body.

We cover:
• How Ipamorelin, Sermorelin, Tesamorelin & CJC-1295 stimulate your pituitary
• Why GH peptides are signals, not steroids
• The difference between GH release vs IGF-1 muscle growth
• How IGF-1 LR3 and...

Your pituitary gland and HPA axis control nearly every hormonal signal in your body — from stress and metabolism to growth, reproduction, and long-term healthspan.

In this episode of The Human 5.0 Project, Ultimate Biohacker 10X delivers a clear, clinician-grade breakdown of how the pituitary gland actually works — without fluff or fear-mongering.

You’ll learn:
• The difference between the posterior and anterior pituitary
• How neural vs portal signaling controls hormone precision
• ADH and oxytocin — water balance, bonding, and mood
• Growth hormone, thyroid signaling, cortisol, and the HPA axis
• How chronic stress rewires hormone output
...

The Gut Microbiome Explained: Why Your Health Starts in Your Intestines

Your gut microbiome isn’t just about digestion — it’s a living ecosystem of over 38 trillion microorganisms that regulate nearly every system in your body. From hormones and immunity to inflammation, metabolism, and even mood, your gut bacteria quietly shape your health from the inside out.

In this episode, we take a deep dive into the intestinal microbiome (oral microbiome coming next) and break down what the science actually shows.

Inside this episode:
• When researchers discovered that gut bacteria outnumber...

Methylation Explained: Testing, MTHFR, Methylated Vitamins & the Gut-Brain Connection

Ever feel like low energy, mood swings, or brain fog is holding you back? It might be methylation – the body's core biochemical process for gene regulation, detox, and neurotransmitter balance. In this 12-minute episode, we break down what methylation is, how to test for deficiency (MTHFR & homocysteine), if testing even matters, why methylated vitamins (like methylfolate & methyl-B12) outperform regular forms for many, and the gut's surprising role (bacteria in yogurt don't methylate, but microbiome influences epigenetics via B vitamins & metabolites).

Key takeaways:

• Methy...

The peptide revolution is here — and it’s changing how elite athletes, biohackers, and longevity clinicians approach healing, fat loss, and performance.

In this episode of The Human 5.0 Project, we break down the Top 10 Most Powerful Peptides of 2025, based on real-world use, clinical data, and years of hands-on experience — not hype.

You’ll learn what actually works, what’s overrated, and how advanced protocols are being used responsibly to optimize recovery, metabolism, and long-term health.

• BPC-157 & TB-500 – The “Wolverine Stack” for tendon, ligament, and gut repair
• Semaglutide (Ozempic) –...

Microglia Are Controlling Your Anxiety — The Brain’s Hidden Immune Switch

What if anxiety, OCD, and chronic stress aren’t just “mental” — but immune disorders of the brain?

In this episode of The Human 5.0 Project, we break down groundbreaking 2025 research revealing that microglia — the brain’s immune cells — act as biological “brakes” or “accelerators” for anxiety and compulsive behavior. When these cells malfunction, anxiety and obsessive behaviors can spiral out of control.

Drawing from landmark work by Nobel laureate Mario Capecchi, this episode explores how Hoxb8 microglia regulate emotional behavior — and how dysfunction in this syste...

FDA Removes HRT Black-Box Warning: The 20-Year Misinterpretation That Cost Millions of Women Their Health (2025 Update)

What if hundreds of thousands of women suffered needlessly for two decades because of a misinterpreted study?

For decades, women were told hormone therapy was dangerous — but the science never supported the fear. In this episode, we expose the truth behind the HRT scare, the FDA’s quiet reversal, and why modern hormone optimization is one of the most powerful tools for women’s health today.

Key takeaways:

• The WHI misinterpretation: Progestin arm risks were incorrec...

Could gene editing be the key to slowing — or even reversing — human aging?  What if aging wasn't inevitable decline – but a manageable process we could rewrite? In this deep-dive episode, we explore The Promise of a Longer, Healthier Life through CRISPR gene editing – the revolutionary tool turning longevity from science fiction into scientific frontier.

Key highlights: • CRISPR basics: How it precisely snips and replaces genetic code linked to age-related diseases • Targeting the "Hallmarks of Aging": Senescent cells, mitochondrial dysfunction, telomere shortening • Top genetic targets: FOXO3, sirtuins, telomeres – the genes scientists are editing for extended healthspan • Healthspan vs. lifespan: Why healt...

Peptides are nature's signaling molecules – short amino acid chains that guide repair, regeneration, and resilience without overriding physiology. In this functional overview, we break down the most important biologically active peptides by length (dipeptides to decapeptides), focusing on Professor Vladimir Khavinson's groundbreaking Russian bioregulators and their real-world roles in longevity, immune balance, neuroprotection, and tissue repair.

Key highlights: • Dipeptides like Carnosine (antioxidant) and Vilon (immune/endothelial) • Tripeptides including GHK (collagen/wound healing) and Pinealon (brain protection) • Tetrapeptides: Epitalon (telomerase), Cartalax (cartilage), Prostamax (prostate) • Heptapeptides: Semax (BDNF boost) and Selank (anxiolytic) • Nonapeptides: Oxytocin & Vasopressin • Decapeptides: GnRH & Kisspeptin-10

We explore d...

Joint Regen 2.0: Why Eating Nuts & Seeds Won't Fix Your Cartilage After 40 (The Real Stack That Does)

Tired of joint stiffness, aches, and slow recovery creeping in after 40? You're not alone – but the viral "just eat more seeds" advice isn't the answer.

In this episode, we bust the myth that nuts and seeds alone can regenerate collagen and cartilage (spoiler: ALA omega-3 conversion is tiny, and human trials are basically nonexistent). Instead, we reveal the proven protocol clinics are using in 2025 to rebuild joints: collagen peptides, MSM, glucosamine/chondroitin, hyaluronic acid, and game-changing peptides BPC-157 + Cartalax.

Apple cider vinegar has been hyped as a miracle cure for weight loss, blood sugar control, and longevity — but what does the science actually say?

In this episode of The Human 5.0 Project, we break down the real research behind apple cider vinegar, including why recent high-profile studies were retracted, what benefits are real, and what’s pure internet myth.

You’ll learn:
• Why a major ACV weight-loss study was pulled
• What acetic acid really does in the body
• Whether ACV actually helps blood sugar or metabolism
• Why it won’t “boost metabolism” or ext...

Canadian researchers have uncovered a surprising new driver of metabolic disease — and it’s not sugar, fat, or calories.

In this episode of The Human 5.0 Project, we break down groundbreaking 2025 research revealing how D-lactate, a little-known byproduct of gut bacteria, may quietly drive insulin resistance, fatty liver disease, and metabolic dysfunction.

This isn’t hype — it’s a fundamental shift in how we understand metabolism.

• How gut microbes produce D-lactate — a previously overlooked metabolic signal
• Why D-lactate disrupts glucose regulation and fuels fatty liver disease
• How researchers used...

Epitalon (also known as Epithalon) is the synthetic tetrapeptide from Vladimir Khavinson’s Russian labs that’s making waves in 2025 for its potential to extend telomeres, optimize sleep, and promote healthy aging.

In this 12-minute episode, we’ll dive into:

The origin story: Khavinson’s 1980s discovery at the St. Petersburg Institute (correcting common misconceptions)

50+ years of research: Lifespan extension in animal models, human telomere findings, and 2025 trials on epigenetic aging

How it’s being used in longevity and functional medicine

Legal status: Approved in Russia/Ukraine, research-only elsewhere

St...

What if your mindset is the missing variable sabotaging your results?

In this episode of The Human 5.0 Project, we break down Mindset Medicine — the science-backed mental frameworks that amplify the effectiveness of supplements, peptides, red light therapy, fasting, and other performance tools.

This isn’t motivational fluff.
It’s applied neurobiology.

You’ll learn how perception, expectation, and nervous-system regulation directly influence healing, cognition, and recovery — and how to harness them intentionally.

• Why mindset can amplify or block biological healing
• The neuroscience of placebo, expectation, a...

Cerebrolysin – the porcine-brain-derived peptide complex used in over 50 countries for stroke, TBI, dementia, Long COVID brain fog, and elite neuro-regeneration – but still not FDA-approved in the United States.

In this 15-minute masterclass, we cover:

1950s Soviet military origins & Professor Khavinson's revolution

60+ years of clinical data (hundreds of trials, millions of doses)

Exact mechanisms: 80% neurotrophic factors identical to human BDNF, NGF, IGF-1

Current 2025 protocols for TBI, stroke recovery, Long COVID cognition, anti-aging

Optimal dosing (5–30 ml), IM vs IV, best stacks (Pinealon, Semax, SS-31, Dihexa)

Why the FDA sa...

Pinealon is a Russian tri-peptide bioregulator developed for military brain resilience that’s now gaining global attention for neuroplasticity, brain fog, Long COVID cognition, and healthy aging in 2025.

Originally created by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology, Pinealon has over 40 years of research and real-world use behind it.

In this episode of The Human 5.0 Project, we break down:
• The full history of Pinealon from Soviet labs to modern clinics
• Decades of Russian research plus a 2024 Italian human pilot study
• How Pinealon supports BDNF, melatonin rhythm, EEG normaliz...

Semax and Selank (often labeled C-Max and C-Link) are Russian nootropic peptides dominating 2025 Long COVID, brain fog, and anxiety protocols.

Developed in Moscow over 30 years ago, these peptides are prescription medications in Russia but remain research-only in the United States.

In this episode of The Human 5.0 Project, we break down:
• The full history and 300+ Russian studies
• How Semax increases BDNF and neuroplasticity
• How Selank calms anxiety without sedation
• Why they’re being used in Long COVID and post-viral brain fog
• How they stack with Dihexa, Cerebrolysin, and Pinealon
• The global regulat...

SS-31 (Elamipretide) in 2025: The FDA-Approved Mitochondrial Reset for Long COVID and ME/CFS

Description:
Welcome back to The Human 5.0 Project! In this episode, we dive into SS-31 (Elamipretide) — the peptide that became the first FDA-approved mitochondrial repair therapy for a rare disease in 2025, and how it’s transforming our understanding of fatigue medicine.

In this episode, we cover:

Why SS-31 exploded in 2025 and the human data behind it

How SS-31 works inside mitochondria to restore energy production and reduce post-viral crashes

The exact labs that s...

TB-500 + TB4: Rapid Joint Repair, Hair Growth Signals, and Brain Fog Improvements? What 2025 Data Shows

TB-500 and Thymosin Beta-4 (TB4) are peptides originally studied for tissue repair and immune signaling — and in 2025, they’re gaining attention for their potential roles in joint recovery, hair density support, and cognitive clarity.

In this episode of The Human 5.0 Project, we break down:
• What TB-500 and TB4 actually do at the cellular level
• 2025 human and pilot data on tendon healing, inflammation reduction, and neurovascular support
• Why athletes, clinicians, and biohackers are using these peptides as part of a repai...

If you’ve had COVID and now feel like your brain is wrapped in cotton — words vanish mid-sentence, simple tasks feel overwhelming, and mental fatigue hits after just minutes — you’re not alone.

This is Long COVID brain fog, still affecting an estimated 10–20% of everyone infected since 2020 — over 100 million people worldwide.

In this deep-dive episode of The Human 5.0 Project, we break down what’s actually happening in the brain, why many standard evaluations miss it, and the 2025 clinical and functional medicine protocols that are helping people recover cognitive clarity.

• The...

"Unveiling the Hidden Causes and Advanced Approaches for Better Thyroid Health"

In this episode of The Human 5.0 Project, we dive deep into Hashimoto’s thyroiditis, exploring the hidden causes that mainstream medicine often overlooks. Discover why T4-only therapy may not be enough, the importance of comprehensive lab testing, and cutting-edge strategies that are changing the way we approach thyroid health in 2025.

Key Points:

The hidden timeline of Hashimoto’s and why early immune markers matter.

Why standard treatments often fail and the role of T3 and desiccated thyroid.

Inno...

Is depression really a “serotonin problem”… or something your doctor didn’t check?
In today’s episode, we’re breaking down the five real biological and lifestyle pathways that can mimic depression—and why SO many people get put on meds before anyone even runs basic labs.

As a retired MD who has seen countless rushed admissions and missed diagnoses, I’m pulling back the curtain on what depression often really is:
• Metabolic dysfunction
• Nutrient deficiencies
• Inflammatory brain stress
• Loneliness-driven cortisol overload
• Medication side effects

This deep dive gives you the exact roadmap to i...

Microplastics are now in our food, water, air—even our bloodstream. In this episode, we break down exactly where microplastics come from, how they enter the human body, the health risks they pose, and the emerging science on removing them.

We also cover:
• The top home and lifestyle sources of microplastics
• How to detox microplastics naturally
• What works, what doesn’t, and what’s emerging
• House and lifestyle upgrades to reduce plastic load
• How microplastics affect hormones, inflammation, mitochondria, fertility, and aging
• Biohacker strategies to protect your cells and extend your healths...

The Cellular Energy Masterclass: NAD+ Precursors for Peak Performance & Healthspan

In this deep-dive episode, we break down the full science behind NAD+, the molecule your mitochondria depend on for energy, repair, and metabolic resilience. We compare major NAD+ precursors—NMN, NR, Niacin, Niacinamide, NADH—and explain how each works, how they differ, and how to use them strategically for peak performance and extended healthspan.

🔥 What you’ll learn:
• What NAD+ actually does inside your cells
• Why NAD+ declines with age — and how to reverse it
• NMN vs NR vs Niacin vs NADH: Mechanisms & diff...

GLP-1 Showdown: Semaglutide vs Tirzepatide vs Retatrutide (+ Cagrilintide, Mazdutide, Survodutide) | Ultimate Biohacker 10X

In today’s episode of The Human 5.0 Project, we break down the ultimate incretin showdown — the real science behind the world’s most powerful metabolic and longevity drugs. Whether you're exploring Semaglutide, Tirzepatide, Retatrutide, CagriSema (Cagrilintide + Semaglutide), Mazdutide, or Survodutide, this episode gives you everything you need to understand which one fits your goals.

🔥 What You'll Learn:
• How GLP-1, GIP, glucagon, and amylin pathways really work
• Which compounds deliver the highest weight-loss percentages
• Longevity benefits: inflammation reduction, heart protection, metabolic reset...

Are synthetic drugs silently overwhelming your body’s detox machinery?
In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down the real difference between natural biological pathways and lab-created pharmaceuticals — and why your body reacts so differently to each one.

We dive deep into how the liver’s cytochrome P450 enzymes act as your internal garbage disposal system, processing hormones, toxins, plant compounds… and unfortunately, most pharmaceutical drugs. When these enzymes get overloaded, everything from hormone balance to detoxification to metabolic health starts breaking down.

Inside this episode you’ll learn:

🔥 Why pe...

In this episode of The Human 5.0 Project, we dive deep into SLU-PP-332, a groundbreaking compound that promises to revolutionize metabolic health and longevity. Dosing in notes.

Origins and Development: Discover how SLU-PP-332 was developed at Saint Louis University and the brilliant minds behind it.

Mechanism of Action: Learn how this compound mimics exercise at the cellular level, boosting mitochondrial function and metabolic health.

Current Applications: Explore the therapeutic uses of SLU-PP-332 and how it compares to other metabolic therapies.

In this episode of the Human 5.0 Project, we delve into the complex world of ALS (amyotrophic lateral sclerosis). We start with a brief overview of what ALS is, and then we explore the current standard treatments, including medications like Riluzole and Edaravone. The heart of the episode focuses on the innovative supportive therapies being used in the U.S.—from functional medicine and nutritional supplements to cutting-edge peptides and their role in supporting neuron health. We also look into the exciting research and future directions, including stem cell therapies and their potential to transform ALS care. Join us as we...

In this episode of The Human 5.0 Project, we unpack one of the most controversial molecules in modern medicine: nicotine.
Not smoking. Not vaping. Nicotine itself.

For decades, nicotine has been labeled as “highly addictive” by the FDA and Surgeon General—but emerging research from the 1990s through 2025 paints a far more complex picture. We dive into:

• Big Tobacco documents revealing how additives—not nicotine—supercharged dependence
• Why pure nicotine behaves differently from cigarette-delivered nicotine
• How NRT (patches, gum) shows almost zero abuse potential
• Neuroprotective effects in Alzheimer’s, Parkins...

Welcome back to The Human 5.0 Project! In today’s episode, we’re diving deep into Thymosin Alpha-1 (TA1)—the immune-modulating peptide that’s been quietly revolutionizing immune resilience for decades.

We cover:

The fascinating history of TA1: From its discovery in the 1970s to its role in 2025 as a trusted tool for biohackers and longevity enthusiasts.

How TA1 works: We break down how this 28-amino-acid peptide acts as the conductor of your immune system, fine-tuning T-cells, NK cells, and cytokines for a balanced, anti-inflammatory response.

Dosing protocols for everything from acute viral in...

In this 9-minute episode, we break down Semaglutide (Ozempic/Wegovy/Rybelsus) — the GLP-1 agonist that reshaped weight loss, longevity, and metabolic health. Even as newer peptides like Tirzepatide and Retatrutide enter the spotlight, Semaglutide remains a proven, reliable, and highly effective tool for weight management and healthspan optimization.

We cover everything you need to know:
✔️ What Semaglutide is & how it works
✔️ Why it’s STILL relevant despite newer multi-agonists
✔️ Dosing protocols for weight loss & diabetes
✔️ Side effects & how to minimize them
✔️ The best stacks for muscle retention, longevity, & metabolic health
✔️ The 2025 biohacking trend: microdosin...

Welcome back to The Human 5.0 Project – where we upgrade the human operating system.

In today’s episode we go full-send on Retatrutide , Eli Lilly’s triple-agonist that just obliterated every weight-loss record in 2025: up to 24.2% body weight loss in 48 weeks (that’s 50–60+ lbs for most people) with simultaneous improvements in A1c, liver fat, blood pressure, and triglycerides. People are already calling it the “Ozempic killer” and the first true “programmable metabolism” molecule.

Here’s exactly what we cover in this 9-minute deep dive:

In this 5-minute deep dive, we unpack GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper), the copper-bound tripeptide that’s absolutely dominating 2025 longevity and aesthetic medicine conversations. Once a well-kept secret of high-end skincare, GHK-Cu is now the #1 most-researched regenerative peptide worldwide — and for good reason.

Here’s exactly what we cover:

Dive into the world of Vilon, one of the original Khavinson peptides, in this focused seven-minute breakdown. We cover what it does (Lys-Glu dipeptide from thymus extracts), how it works (chromatin remodeling, gene upregulation), and the exact research dosing protocols used in cell cultures and rodents. If you're into longevity, immunosenescence, or peptide stacks, this episode unpacks the science behind restoring youthful immune function.  Like, subscribe, and comment your favorite bioregulator below!

For more longevity insights and protocols, check out biohackerdepot.com – your go-to resource for cutting-edge health optimization strategies.

And if yo...

In this episode, we dive into holistic approaches to managing Crohn’s disease and related inflammation. From peptides and supplements to diet and lifestyle tweaks, discover how you can create a balanced, integrative plan for symptom relief without relying solely on heavy-duty medications. Always discuss treatment plans with your healthcare provider.

#CrohnsDisease #Inflammation #HolisticHealth #Peptides #DietAndLifestyle #GutHealth #AutoimmuneHealing

In this episode, we dive deep into the world of Ipamorelin, a powerful peptide known for boosting growth hormone levels, enhancing recovery, and supporting anti-aging. Whether you're curious about how it works, the benefits, or the potential drawbacks, we've got you covered in a quick seven-minute deep dive.

#Ipamorelin #Peptides #Biohacking #Longevity #HumanPerformance #Wellness #PodcastLife

In this episode of The Human 5.0 Project, Ultimate Biohacker 10X breaks down MOTS-c — a mitochondrial peptide that’s making waves in the longevity and metabolic health communities. Learn how this small but mighty peptide works, why researchers are excited about its potential benefits for metabolism, insulin sensitivity, and healthy aging, and what current research says about dosing and safety. Remember, MOTS-c is still in the experimental stage, so always consult a professional before exploring any new peptide protocols.

#MOTSc #Biohacking #Longevity #Mitochondria #Peptides #MetabolicHealth #HumanOptimization #UltimateBiohacker10X #TheHuman50Project #Wellness #HealthScience

BPC-157 is one of the most talked-about peptides in the biohacking, longevity, and performance science world — yet most people still don’t understand what it actually does or how it works. In this episode, I break down the real science behind BPC-157, separating hype from reality and giving you a clear understanding of its role in regeneration, recovery, and gut health.

We explore the origins of BPC-157, how it’s derived from a naturally occurring protective protein in the stomach, and why researchers have been fascinated by its effects on healing, inflammation, and tissue repair. You’ll learn ho...

The KLOW Peptide has become one of the most talked-about compounds in the optimization and performance world — but most people still have no idea what it actually does or how it fits into the KLOW framework. In this episode, I break down the science behind the KLOW Peptide, how it works, the pathways it influences, and why it’s gaining so much attention in the biohacking community.

You’ll learn how the KLOW Peptide interacts with the four pillars of the KLOW Protocol:
K — Ketosis
L — Low Insulin
O — Optimal Hormones
W — Weight Management & W...