The Science of Age-less Living

In this episode of The Science of Ageless Living, Dr. Ethan Hausman-Marquis unpacks autoimmune fatigue in conditions like MS, lupus, and rheumatoid arthritis—and why it’s so often misunderstood. Fatigue isn’t laziness or deconditioning; it’s a biological safety response to chronic inflammation.

He explains how inflammation disrupts neurotransmitters, autonomic balance, and oxidative stress, with mitochondria at the center. In autoimmune disease, mitochondria intentionally downshift energy production to protect cells from damage—an intelligent adaptation, not failure.

A key takeaway: more energy isn’t always better. Aggressive interventions like NAD+ or stimulants can override the...

Why do we age? Is it simply the passage of time — or something far more precise, and far more modifiable?

In this episode of The Science of Age-less Living, Dr. Ethan Hausman-Marquis takes you deep into the real biology of aging, revealing why growing older is not an inevitable countdown, but a consequence of accumulated cellular damage and declining repair capacity.

You’ll learn why aging is best understood as a systems-level failure — a breakdown in information, energy, and repair — rather than a single disease. We explore how DNA damage accumulates over time, why epigenetic regulati...

Dr Ethan Hausman-Marquis dismantles the hype around MTHFR in this evidence-based 16:30 talk. Learn what MTHFR actually does, what common variants like C677T and A1298C mean, how homocysteine, folate, B12 and lifestyle shape risk, and when testing or targeted supplementation is appropriate. Perfect for evidence-based health seekers confused by genetic marketing and “methylation” protocols—this calm guide shows how to integrate MTHFR responsibly into clinical care without fear or oversimplification. Watch for clear clinical vignettes, practical treatment principles, and communication tips for patients. If this helped, please like and share with someone told they “have MTHFR.”

#MTHF...

Dive into SS-31 Explained: Unlock Youthful Energy at the Mito Level — a 6:45 deep-dive on SS-31 (Elamipretide), mitochondrial health, and the latest 2025 clinical updates. Dr. Ethan breaks down mechanisms, preclinical wins, human trials, safety, and real-world anti-aging potential for longevity seekers (35–65). Learn how SS-31 targets cardiolipin, reduces ROS, boosts ATP, and why FDA approval for Barth syndrome matters for mitochondrial medicine. Perfect for anyone curious about mitochondrial dysfunction, sarcopenia, HFpEF, AMD, and translational longevity science. Like and share if you found this useful. #SS31 #Elamipretide #Mitochondria #Longevity #AntiAging #BarthSyndrome #MitochondrialHealth

OUTLINE:

00:00:00 Opening and Episode Intr...

Forget Peptides—Sleep Is the Real Longevity Hack — Dive into this episode of The Science of Age-less Living: a 27:30 deep-dive using stock visuals that unpacks why restorative sleep outperforms trendy fixes like peptides and stem cells for healthspan, cellular repair, cognitive resilience, and hormonal balance. Evidence-driven, practical, and tailored for longevity enthusiasts and biohackers, this episode covers sleep science, glymphatic clearance, telomeres, sleep hygiene tips, CBT‑I, wearables, and real-world strategies to optimize circadian rhythm. Follow the script word-for-word for a focused, actionable listen. If this helped you rethink your bedtime, please like and share with fellow biohackers. #Longevity #SleepH...

Join Dr. Ethan at The Catalyst Clinic for "Precision Longevity: Real Cases, Real Results" — a deep dive into evidence-based longevity medicine. Follow patient case studies on tendon regeneration, chronic fatigue, hair/skin restoration, and cognitive recovery using precision diagnostics, NAD+, targeted peptides (BPC-157, TB-500, MOTS-c, SS-31, GHK-Cu, KPV, Semax, Selank), red-light therapy, exosomes, and AURION™ AI-guided protocols. Learn how systems-level medicine, mitochondrial support, circadian optimization, and nutrition combine to restore function, resilience, and quality of life for longevity seekers aged 35–55. Like and share if this brought clarity or hope. More at thecatalystclinic.com. and Instagram @thecatalytclinic #Longevity #PrecisionMedicine #PeptideTherapy #NAD #R...

Dr. Ethan breaks down the science behind reversing biological age in The Age-less Code: Reversing Time with Peptides, Stem Cells & Gene Therapy. This episode from The Catalyst Clinic explores peptides (BPC-157, TB-500, GHK‑Cu, Epithalon), stem cells & exosomes, and gene/epigenetic therapies—connecting practical clinical use with the future of longevity and regenerative medicine. Ideal for longevity seekers (35–65) curious about biological age, NAD, sirtuins, exosome therapy, and personalized protocols. All visuals use licensed stock media. Like and share if you found this valuable. Learn more at thecatalystclinic.com and follow @thecatalystclinic for updates. #Longevity #RegenerativeMedicine #Peptides #StemCells #GeneTherapy

Dive into the remarkable world of peptides with Dr. Ethan in this enlightening episode of "The Science of Age-less Living." While BPC-157 and TB-500 often steal the spotlight, we'll uncover the hidden potential of KPV and VIP—two lesser-known peptides that hold incredible promise for healing and regeneration. Discover how KPV acts as an anti-inflammatory powerhouse, promoting gut health, while VIP serves as a multi-system modulator affecting everything from the brain to the immune system. Join us as we explore the science behind these game-changing compounds and their therapeutic applications. Like this video and share your thoughts in the co...

Dr. Ethan breaks down epigenetics and how your daily choices shape biological age in this 19:45 deep-dive. Learn DNA methylation, histone modification, non-coding RNAs, epigenetic drift, methylation clocks (Horvath, GrimAge), and practical lifestyle levers—nutrition, exercise, sleep, stress management, and environmental hygiene—to “rewrite” your cellular code. Explore cutting-edge therapies like peptides, NAD+ micro-dosing, senolytics, and partial reprogramming, plus consumer methylation tests and future epigenetic editing. Perfect for health-conscious adults 35+ seeking science-backed longevity strategies and actionable tips. If this episode helped, please like and share with someone you care about. Visit The Catalyst Clinic for more resources.

Dr. Ethan breaks down how peptide therapy is transforming perimenopause care—targeting hormone balance, mitochondrial function, inflammation, sleep, cognition, libido, and metabolic health. This 38:15 deep-dive covers Epitalon, DSIP, Semax, Selank, Kisspeptin-10, CJC-1295 + Ipamorelin, PT-141, BPC-157, Thymosin Alpha-1, NAD+ support, and practical protocols used at The Catalyst Clinic. If you’re a woman 35–55 navigating perimenopause, learn precision approaches to reduce brain fog, restore energy, protect bone and muscle, and optimize long-term health. Like and share if you found this helpful—help other women discover science-led options for thriving through midlife. #Perimenopause #PeptideTherapy #Longevity #WomensHealth #Mitochondria

00:00:00 Opening

00:02:04 Differen...

Summary: The Science of Age-less Living — The Promise of Senolytics

In this episode, Dr. Ethan Hausman-Marquis, cosmetic surgeon, professor, and founder of The Catalyst Clinic, explores one of the most exciting frontiers in longevity medicine: senolytics—therapies designed to selectively eliminate aged, dysfunctional “zombie cells” that accumulate in our bodies as we age.

OUTLINE:

00:00:00 Introduction and Credentials

00:01:15 Scientific Foundation

00:02:13 Understanding Senescent Cells

00:06:14 Senolytics Introduction

00:10:12 Clinical Evidence

00:14:33 Cosmetic and Regenerative Applications

00:17:58 Ethical and Regulatory Considerations

00:21:20 Future Outlook

00:23:14 Conclusion and Wrap...

Dive into polygenic risk scores (PRS) and discover how your genetic blueprint can inform personalized longevity strategies. Dr. Ethan Hausman-Marquis breaks down genome sequencing, five major genetic pathways to aging (DNA repair, metabolism, inflammation, mitochondria, neurodegeneration), and real-world clinical applications from The Catalyst Clinic.

Learn how PRS can shift prevention from one-size-fits-all to truly individualized interventions—while understanding limits like population bias and probabilistic risk. Perfect for longevity science fans curious about precision medicine, NAD+, peptides, and building cognitive and mitochondrial resilience. If this episode helped you, please like and share with someone interested in age-less living. #Po...

Join Dr. Ethan as he delves into the science of Retatrutide, a groundbreaking synthetic peptide developed by Eli Lilly.

This episode unpacks how Retatrutide targets three key hormone receptors—GLP-1, GIP, and glucagon—revolutionizing approaches to weight management, glucose regulation, and metabolic health. Explore the molecular biology, receptor targets, and clinical trial results that set Retatrutide apart from drugs like Semaglutide (Ozempic) and Tirzepatide (Mounjaro). Whether you’re a clinician, student, or just curious about the future of obesity and diabetes treatment, this accessible overview illuminates the intersection of chemistry, biology, and innovative drug design. Like and share...

In this episode of The Science of Age-less Living, Dr. Ethan—doctor, molecular biologist, athlete, and regenerative medicine expert—explores the fascinating world of peptides and their essential role in cellular health, performance, and longevity. This episode demystifies peptides, describing them as short chains of amino acids that function as “project managers” within our cells. Using engaging construction site analogies, Dr. Ethan explains how peptides are created from DNA instructions, undergo precise modifications, and are tightly regulated to perform specific tasks. Unlike proteins, peptides are shorter and act mainly as messengers and coordinators, directing when and how cells grow, heal, an...

This podcast episode of "The Science of Age-less Living," hosted by Dr. Ethan , delves into the burgeoning world of peptide therapies and their role in modern medicine, particularly in the context of longevity and wellness. The discussion highlights the science behind peptides—short chains of amino acids with targeted effects on bodily processes—and contrasts their rapid rise in the wellness community with the traditional, cautious approach of Big Pharma. Through real-world case studies, market data, and expert insights, the episode explores whether peptides are a disruptive force or a complementary innovation, examining regulatory challenges, safety concerns, and rampant misi...

Are NAD+ supplements the key to age-less living, or could they pose a cancer risk? In this episode of "The Science of Age-less Living," Dr. Ethan Hausman-Marquis delves into the complexities surrounding nicotinamide adenine dinucleotide (NAD+).

Discover its crucial role in energy production, DNA repair, and cellular health, as well as the rising popularity of NAD+ supplements.

We’ll examine the scientific evidence linking NAD+ to cancer growth and discuss the implications for those with a history of cancer. With caution advised for certain individuals, learn how to navigate the fascinating landscape of NAD+ supplementation.

Discover the groundbreaking potential of Retatrutide in our latest episode of "The Science of Age-less Living"! Join Dr. Ethan Hausman-Marquis as we explore this innovative triple-hormone medication that's changing the game in weight loss and metabolic health. With average weight reductions of 24.2% in just 48 weeks, Retatrutide is outpacing popular treatments like Ozempic and Mounjaro. We'll dive into its unique mechanism, the impressive clinical trial results, and why it's capturing the attention of bodybuilders and fitness enthusiasts alike. Don't miss this comprehensive overview of Retatrutide's benefits, risks, and future in obesity treatment!

#Retatrutide #WeightLoss #MetabolicHealth #HealthWellness...

Today's episode is particularly special because Dr. Ethan will dive into something that could be a complete game-changer for many of you: AOD 9604 – The Age-less Fat-Loss Peptide You Haven't Heard Of, But Should – Your GLP-1 Alternative.

If you've been frustrated by stubborn body fat, priced out of popular weight-loss medications, or simply looking for science-based alternatives to achieve the body composition you've been working toward, this episode is specifically for you. We're going to explore a peptide that's been flying under the radar but offers remarkable potential for targeted fat loss without the complications or accessibility issues of m...

Can a peptide hold the key to age-less vitality? Join Dr. Ethan on The Science of Age-Less Living as he delves into the science behind testosterone's crucial role in aging and explores the potential of Testagen, a peptide bioregulator, to support natural testosterone function. Discover the theoretical mechanisms, potential benefits for energy, muscle, and overall well-being, and the critical importance of approaching such interventions with caution and expert medical guidance.

00:00:00. Introduction to Age-Less Living

00:00:30. The Quest for Longevity

00:00:49. The Role of Testosterone

00:01:05. Understanding Testosterone

00:01:29. The Challenge of Aging

Can a peptide hold the key to age-less vitality? Join Dr. Ethan on The Science of Age-Less Living as he delves into the science behind testosterone's crucial role in aging and explores the potential of Testagen, a peptide bioregulator, to support natural testosterone function. Discover the theoretical mechanisms, potential benefits for energy, muscle, and overall well-being, and the critical importance of approaching such interventions with caution and expert medical guidance.

00:00:00. Introduction to Age-Less Living

00:00:30. The Quest for Longevity

00:00:49. The Role of Testosterone

00:01:05. Understanding Testosterone

00:01:29. The Challenge of Aging

Today, Dr Ethan dives into a topic that's close to his heart, and likely to many of yours: ADHD. For decades, stimulants have been the go-to treatment, but what if there's more to the story? What if we could support brain function in a way that complements, or even transcends, traditional approaches?

In this episode, we're going beyond the familiar, and venturing into the realm of NAD+. Yes, that NAD+ – the cellular powerhouse we often associate with longevity. But could it also be a key player in managing ADHD? We'll explore the science, the potential benefits, and th...

In this episode, we delve into the cutting edge of aging research, exploring a truly groundbreaking molecule: FOXO4-DRI. This peptide has the scientific community buzzing with its potential to fundamentally reshape our understanding of aging and cellular health by targeting rejuvenation at the most basic level. Join us as we unpack the science behind FOXO4-DRI and its implications for our quest to not just live longer, but better.

OUTLINE:

00:00:00 Introduction

00:00:57 The Quest for Longevity

00:01:23 Understanding Cellular Senescence

00:02:37 Introducing FOXO4-DRI

00:03:06 The Science Behind FOXO4-DRI<...

In this episode, we delve into the cutting edge of aging research, exploring a truly groundbreaking molecule: FOXO4-DRI. This peptide has the scientific community buzzing with its potential to fundamentally reshape our understanding of aging and cellular health by targeting rejuvenation at the most basic level. Join us as we unpack the science behind FOXO4-DRI and its implications for our quest to not just live longer, but better.

OUTLINE:

00:00:00 Introduction

00:00:57 The Quest for Longevity

00:01:23 Understanding Cellular Senescence

00:02:37 Introducing FOXO4-DRI

00:03:06 The Science Behind FOXO4-DRI<...

In this episode of "The Science of Age-Less Living," Dr. Ethan explores the revolutionary world of bioregulatory peptides. These short chains of amino acids act as messengers within the body, regulating crucial biological processes. The podcast delves into the science behind these peptides, explaining how they function as a "communication network" for cells, promoting healing, enhancing recovery, and boosting immune function. Dr. Ethan discusses the applications of peptides in medicine, showcasing their ability to accelerate tissue repair (BPC-157), modulate immune responses (Thymosin Alpha-1), and slow degenerative diseases.

The episode further examines the transformative impact of peptides in...

Discover the science behind caloric restriction and its profound impact on longevity in this video. Join Dr. Ethan as he unpacks the intricate biochemical pathways—like insulin signaling and the mTOR pathway—that connect calorie intake to aging. Learn how reducing calories (without sacrificing nutrients) can lower oxidative stress, inflammation, and promote cellular repair. Whether you're curious about optimizing health or extending lifespan, this episode is your guide to living an "Age-Less" life. Don't miss practical tips on implementing caloric restriction safely for a healthier future!

OUTLINE:

00:00:00 Introduction

00:02:29 Understanding Caloric Restriction

00:06:41 Bioc...

Join Dr. Ethan, a leading medical innovator and aesthetic and longevity pioneer, in this enlightening episode of The Science of Age-Less Living, where we explore the fascinating biology of aging and the cutting-edge therapies that aim to slow it down.

From understanding the roles of cellular senescence and telomere shortening to delving into groundbreaking treatments like Epithalon peptide therapy, senolytics, and stem cell research, this episode unpacks the science behind living longer and healthier lives. Dr. Ethan also discusses the ethical implications of anti-aging therapies and speculates on future breakthroughs in longevity science.

Whether you're...

Welcome to The Science of Age-Less Living, a podcast hosted by Dr. Ethan, a medical innovator and aesthetic pioneer dedicated to unlocking the secrets of living not just longer, but better. Broadcasting from The Catalyst Clinic in London, New York, and Amsterdam, this podcast delves into cutting-edge science and practical strategies for optimizing health and longevity.

In today’s episode, we’re exploring the fascinating world of NAD+—a vital coenzyme central to energy production, DNA repair, and cellular health. As we age, NAD+ levels naturally decline, impacting our metabolism, mitochondrial function, and overall vitality. We’ll uncover...

In this episode, Dr Ethan dive into the transformative world of gene editing—specifically its potential to revolutionize longevity medicine. From the basics of CRISPR technology to cutting-edge research targeting age-related diseases like Alzheimer’s and heart disease, we’ll uncover how gene editing is unlocking the secrets of healthier, longer lives.

We’ll also explore the ethical considerations, societal implications, and public perceptions shaping the future of this revolutionary field.

Whether you’re a scientist, a health enthusiast, or just curious about the possibilities of aging better, this thought-provoking conversation will leave you inspired and inform...

Join Dr. Ethan Hausman-Marquis, a renowned expert with over 30 years of experience in oncological surgery and groundbreaking medical techniques, as he delves into age-less living and enhancing life quality. In this engaging podcast, Dr. Hausman-Marquis discusses the latest in longevity, aesthetics, and regenerative medicine, making complex topics accessible for everyone. Discover the science behind aesthetic treatments like Botox and microneedling, and explore the role of peptides in promoting longevity. Learn about lifestyle choices that influence youthfulness and hear personal anecdotes that blend medicine with real life. Embrace a journey toward vitality and make aging optional with insights from a...

The Science of Age-Less Living" — hosted by Dr. Ethan, medical innovator, aesthetic pioneer, and lifelong explorer of the human body’s incredible potential — is your ultimate guide to living not just longer, but better. Broadcasting from The Catalyst Clinic with locations in London, New York, and Amsterdam, this podcast dives deep into the cutting-edge science of longevity, regenerative medicine, and optimal health.

In this episode, we uncover the secrets of BPC-157, a powerful peptide nicknamed the "miracle molecule" for its extraordinary ability to heal the gut, repair tissues, and even modulate gene expression. Where did it come from...